Glutamate Dehydrogenase as a Marker of Alcohol Dependence
نویسندگان
چکیده
منابع مشابه
Glutamate dehydrogenase as a marker of alcohol dependence.
AIMS The aim of this study was to examine glutamate dehydrogenase (GLDH) in the diagnostic combinations as a result of new findings. METHODS GLDH, gama-glutamyltransferase (GGT), aspartate-aminotranferase (AST), alanine-aminotransferase (ALT) and erythrocyte mean cell volume (MCV) were assessed three times in 238 alcoholics admitted to hospital: on admission, after 24 h and after 7 days. RE...
متن کاملErythrocyte Aldehyde Dehydrogenase = a Potential Marker for Alcohol Dependence
The present study explored the utility of erythrocyte aldehyde dehydrogenase (ALDH) as a peripheral marker in alcoholism. The ALDH levels in aocoholics, their first degree nonalcholic relative and controls were compared. ALDH was found to be significantly lower in alcoholics (3.38±1.70 mU p< 0.001) and their first degree relatives (4.04±1.55 mU p< 0.05) compared to controls (5.06±1 55mU). Low A...
متن کاملThe alcohol dehydrogenase isoenzyme alcohol dehydrogenase IV as a candidate marker of Helicobacter pylori infection
INTRODUCTION Helicobacter pylori infection is associated with decreased alcohol dehydrogenase (ADH) activity in the gastric mucosa. The decrease in gastric ADH activity depends on the severity of inflammation and mucosal injury. This damage can be a reason of the release of enzyme from gastric mucosa and leads to the increase of the ADH activity in the sera of patients with H. pylori infection....
متن کاملThe alcohol dehydrogenase isoenzyme (ADH IV) as a candidate tumour marker of esophageal cancer.
OBJECTIVE Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are present in esophageal cancer cells. Moreover the total activity of ADH as well as the activity of class IV ADH isoenzyme is significantly higher in cancer tissue than in healthy mucosa. The activity of these enzymes in cancer cells is reflected in the sera and could thus be helpful for diagnostics of esophageal cancer. ...
متن کاملAssociation of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis.
Linkage evidence indicated that gene(s) located on chromosome 4q, in the region of the alcohol dehydrogenase (ADH) genes, affected risk for alcoholism. We genotyped 110 single nucleotide polymorphisms (SNPs) across the seven ADH genes and analyzed their association with alcoholism in a set of families with multiple alcoholic members, using the pedigree disequilibrium test. There was strong evid...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Alcohol and Alcoholism
سال: 2009
ISSN: 0735-0414,1464-3502
DOI: 10.1093/alcalc/agp070